The successful selection of drug targets and lead candidates is critically linked to understanding the complexity of disease biology and having insight into biological responses. At Charles River, biologists work directly with medicinal chemists, pharmacologists and toxicologists to evaluate target engagement and drug properties. Using a wide array of biochemical, rodent and human cell-based functional assays, they bring disease-relevant human biology to the forefront of drug discovery. Gene editing, access to patient-derived cells and stem cell-based assays have dramatically expanded the scope of complex in vitro biology that can contribute to a program’s success.

Our integrated bioscience team is experienced at all stages of drug discovery, across the major therapeutic areas and in a full range of targets, allowing us to deliver exceptional science with insight and data you can trust to progress your drug discovery program.

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