ADME Screening

Whether you have one compound or a library of compounds requiring drug metabolism assessment, Charles River can design, conduct and interpret the in vivo pharmacokinetic/ADME components of your program as part of our streamlined non-GLP screening services. Quick study initiation, multiple species, resident animal colonies (with chronic surgical models included) and various dose regimens and administration routes, plus bioanalytical support, provide the necessary tools you need to rapidly identify and optimize potential drug candidates.

  • Bioavailability
  • Biliary excretion
  • Mass balance
  • Tissue distribution
  • Bioequivalence
  • Dose ranging
  • Linearity
  • Proportionality
  • Single, multiple and cassette dosing
  • Metabolite profiling
  • Vascular access ports
  • Chronic bile duct cannulation in nonrodent species
  • Intestinal cannulation
  • Portal vein cannulation
  • Cardiovascular telemetry 

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Pharmacokinetics Studies

All phases of discovery pharmacokinetics can be performed in-house and reports are issued within 5 days of compound dosing.

Bioanalysis Services

Charles River offers non-GLP discovery bioanalytical services either in support of studies conducted in-house or as a stand-alone service.

Non-GLP Toxicity Testing

Basic services in non-GLP bioavailability, pharmacokinetics and toxicity analysis conducted in the spirit of good laboratory practice.