Pharmacokinetics

Charles River provides an integrated approach where all phases of discovery pharmacokinetics (PK) are performed by one organization at one site. Study directors act as the single point of contact and are engaged in PK studies from formulation to data delivery. Final PK study reports are issued within 5 days of compound dosing.

  • Short lead time for pharmacokinetic study initiation
  • Timed dosing by various routes (PO, IV, IP, IM, SC, ICV, etc.)
    • Single agents, cassette dosing, repeat doses
    • Radiolabeled compound capabilities
  • 10-12 sampling time points over 24 hours
    • Rodents – blood, urine, bile, CSF, tissue
    • Nonrodents 
  • Formulation services
    • In-house pharmacy with extensive experience and a wide range of standard vehicle components
  • Samples analyzed by Charles River or returned to client
  • Watson™ utilized for PK analysis and reporting of standard PK parameters (Cmax, Tmax, AUC0-∞, AUClast, VZ, CL, T1/2, bioavailability)
  • Standard report templates are available and all data can be adapted to client’s needs/existing templates.

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