The study and development of anti-angiogenic therapies depends on reliable and reproducible stimulation models of neovascular response. Charles River has several experimental techniques that allow an effective examination of short-term neovascularization and angiogenic response to bFGF, VEGF or other angiogenic stimuli:
Corneal Micropocket Assay
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Hydron pellet prepared with growth factors chosen for specific study requirements
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Surgical implantation of pellet into a corneal micropocket
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Corneal neovascularization measured using slit-lamp microscope
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Short-term study with rapid turnaround times
In Vivo Screens Using Angiogenic-Dependent
Tumor Growth
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Bevacizumab can be used as a positive control.
Metronomic Dosing1
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Long-term, low-level dosing of cytotoxics or other agents of interest to inhibit growth and development of vascular endothelium while avoiding whole-animal toxicity
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Metronomic dose determination for use in efficacy study
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Studies can last up to 90 days
1. Browder, 2000; Cancer Research 60:1878
Testing / Validation Data
Click below to see a sample data set.