Human tumor xenografts (mice)

Our broad range of tumor lines ensures a wide variety of testing alternatives for your agent. Our xenograft model portfolio is evaluated on a regular basis for response to standards of care and this data is available for designing combination studies.

Our scientific staff can assist in selecting the most appropriate model for your agent. Complete profiling of agents can be carried out in a variety of tumor types or in combination with the appropriate clinical agent. 

Efficacy evaluation can be combined with:

  • Hematology (CBC/Diff) analysis
  • Pharmacokinetic or bioavailability sampling and analysis
  • Histopathology or tissue sampling
  • Biomarker screening, sampling or evaluation
Histotype Cell Line*
Bladder SW780
Brain SK-N-AS, U87 MG, U-251
Breast BT474, HCC-1954, JIMT-1, MCF-7,
MDA-MB-231, MX-1
Colon CL-34, COLO 205, DLD-1, HCT 116, HCT-15, HT-29, LoVo,
LS-174T, LS411N, RKO, SW-480, SW-620
Epithelial A-431
Gastric MKN-45, N87, SNU-5
Head and Neck FaDu
Leukemia HL-60, K-562, MOLT-4, MV4-11, SET2
Liver Hep3B, SNU-398
Lung (Non-small cell) A-427, A549, Calu-6, H1299,H1975, H226, H292, H460, H520, H522, H647, H727, H810, HCC-44, 
SK-MES-1, NCI-H2122
Lung (Small cell) H69, H82, H211, H526, SHP-77, DMS 114, H82
Lymphoma Daudi, DoHH-2, Granta 519, Namalwa, Raji B, Ramos,
REC-1, RL, SU-DHL-4, WSU-DLCL2
Melanoma A2058, A375, IGR-37, SK-MEL-5
Mesothelioma MSTO-211H
Multiple Myeloma H929, OPM-2, RPMI 8226
Ovarian A2780, IGR0V1, OVCAR-3, OVCAR-5, SK-OV-3,
TOV-21G
Pancreas BxPc-3, Capan-1, HPAC, KP4, MIA PaCa-2, PANC-1
Prostate 22Rv.1, DU 145, MDA-PCa2B, PC3
Renal 786-0, Caki-1, Caki-2, G-401, G-402
Sarcoma HT-1080, SJSA-1
Thyroid 8505C, FTC-238
Uterine ECC-1, MFE-280

*Note: Specially requested lines can be developed if a model of interest is not among those listed above.

Histotype Cell Line*
Adrenal H295R
Bladder RT112
Brain SF-295, SK-N-MC
Breast HCC70, HCC-1806
Leukemia HEL92.1.7, RS4;11, SET2, THP-1
Liver HuH-7
Lung COR-L23, NCI-H1963, H2009, H1581, H1993
Melanoma CHL-1, COLO 800, IGR-1, IGR-37, SK-MEL-24,
UACC-62
Thyroid K1
Uterine HEC-1-A, HEC-1-B

*Note: Specially requested lines can be developed if a model of interest is not among those listed above.

You May Also Be Interested In...

Biomarker Services

We can support your drug discovery pipeline by providing biomarker analysis in a non-GxP environment.