Radiochemistry

After a single administration, radiolabeled compounds can be used to follow pharmacokinetics and biodistribution profile for several days in the same animal with SPECT/CT. In addition to SPECT/CT, tissue gamma counter analysis can be added in all studies for a more complete biodistribution profile.

Radiolabeled molecules used for PK/biodistribution studies and autoradiography in mice and rats include commercial pre-labeled (3H,14C) and in-house labeled (125I, 123I, 99Tc, 111In) molecules, particles or cells.

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Pharmacokinetics

Charles River provides an integrated approach where all phases of discovery pharmacokinetics (PK) are performed by one organization at one site.

QWBA

Charles River conducts quantitative whole-body autoradiography (QWBA) programs integrated with our preclinical drug metabolism services.