Bleomycin-induced pulmonary fibrosis is the most common experimental study model of human lung fibrosis. While various routes of bleomycin administration will lead to lung fibrosis, Charles River has the most experience with direct intratracheal instillation into the animal’s lungs using a Penn-Century device. This results in acute inflammation, which in turn leads to fibrosis (as assessed by increased collagen deposition in the alveolar region).
We have the capability to deliver test items by multiple routes (e.g., inhalation, intravenous, subcutaneous). Test item efficacy is then monitored by a number of methods:
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Histopathology
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Collagen quantification
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Bronchoalveolar fluid analysis
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Respiratory measurements
We can present study data in a full report or send tabulated data.