Fragment-Based Drug Discovery

Charles River has extensive capabilities in fragment-based drug discovery (FBDD), offering access to expertise in screening, structural biology as well as computational and medicinal chemistry. Our range of orthogonal fragment screening technologies allows us to customize a fragment-based lead discovery solution.

Our fragment-based drug discovery (FBDD) platform provides access to:

Orthogonal Screening Technologies Technologies include thermal shift assay, surface plasmon resonance (SPR) using Biacore™ instrumentation, isothermal titration calorimetry (ITC), NMR, high-concentration biochemical assay and X-ray crystallography
Structural Biology Experience in the development of structure routes to support FBDD; in-house X-ray facility and Crystal Bank of structures
Fragment Library
2,000 member library designed for fragment screening and rapid FBDD optimization of hits
Computational Chemistry Proprietary fragment hit expansion techniques and fragment shape-based analysis tools
Medicinal Chemistry Expertise in structure-based drug discovery and fragment hit optimization

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We conduct hit-to-lead projects in an efficient cycle of rational design, synthesis and biological evaluation.

Integrated Drug Discovery

Integrated Drug Discovery

We operate as a proactive thinking partner bringing target to clinical candidate capabilities, ideas and solutions to your program.