By combining proprietary adenoviral technology with complex cellular assays, Charles River’s target discovery group has delivered novel, validated drug targets in a range of therapeutic areas for over 10 years. We examine the effects of introducing shRNAs (SilenceSelect) or full-length cDNAs (FLeXSelect) contained within our libraries of adenoviruses into human primary cells, differentiated stem cells or cell lines. siRNA and miRNA technologies are also available for gene knockdown studies.

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Phenotypic Screening: Complex and Disease-Relevant Human Primary Cell Assays

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