Drug targets span the entire genome, transcriptome, and proteome and are classified based on their structure and function. Some target classes are implicated across all major disease areas, such as enzymes and kinases. Other target classes are predominantly drug targets in certain disease areas, but sparsely found in other disease areas, such as ion channels in neurology, cardiovascular disease, and respiratory diseases. There is significant variation in the druggability of specific target classes – enzymes and receptors are considered to be easier to modulate compared to GPCRs and ion channels.
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The Charles River Discovery team has extensive experience working across the majority of target classes in multiple therapeutic areas, as well as experience in phenotypic approaches: