Enzymes are widely studied as drug targets, and enzyme modulators are therapeutic options for various diseases. Up to 29% of drug targets are reportedly enzymes belonging to various classes. The most popular enzyme targets include kinases, proteases, and phosphatases. Enzymes have historically been considered attractive targets for therapeutics because of their specificity and druggability primarily due to the presence of a binding pocket and catalytic site. About 250 genes coding for enzymes have been identified as FDA-approved drug targets, further highlighting the continued importance of investigating enzyme targets. Enzymes have been identified as disease drivers across various disease areas, including cancer, neurological disease, autoimmune diseases, cardiovascular disease, and metabolic disorders. Enzyme replacement therapies are currently used in metabolic diseases where the deficiency of a specific enzyme is the primary cause.
Tell Us More About Your Target/Study »
Our cross-functional discovery teams work with a wide range of enzyme targets, including kinases, phosphatases, extra- and intra-cellular proteases, histone, and DNA-modifying enzymes, including gyrases and phosphodiesterases.