Screening Biomarkers

Biomarker assays and analytical readouts are important tools in drug discovery from target validation studies to candidate selection, so the ability to measure with accuracy and sensitivity is essential in making critical go/no-go study decisions. With years of experience in assay design and sample processing, Charles River can support your drug discovery pipeline by providing biomarker analysis in a non-GxP environment.

Whether your study is performed at your facility or designed and implemented at ours, our focus on strategic assay validation/qualification enables us to accurately test your study samples and provide reliable biological translation to your drug discovery program.

Charles River offers a wide range of study-specific analytical services using platforms such as Meso Scale Discovery (MSD®), Luminex®, ELISA, EIA, Western blotting and HPLC. Assays include, but are not limited to:

  • Determination of Nitrite     (Griess)
  • DA, DOPAC, HVA
  • CGRP
  • C99, C83, holoAPP
  • BDNF
  • Aβ1-40, Aβ1-42
  • Ach 
  • 5HT
  • EGF
  • eNOS
  • Eotaxin
  • EPO
  • F-kappaB p65
  • Fractalkine
  • GAPDH
  • G-CSF
  • GLT-1 (GLAST)
  • Glutamate
  • GM-CSF
  • GRO/KC
  • IDE activity assay
  • IFN-γ
  • IGF-I
  • IL-1α, IL-1β, IL-2,
    IL-4, IL-5, IL-6, IL-10,
    IL-12 (p70 or total),
    IL-13, IL-17A, IL-18
  • IP-10
  • KC/GRO/CINC (CXCL1)
  • LDH Measurement
  • Leptin
  • LIX
  • MCP-1
  • MIP-1α, MIP-2
  • NA
  • PGE2
  • Protein Determination Assay
  • P-ser9-GSK3β
  • p-TAU, total TAU
  • RANTES
  • Synaptophysin
  • TGF-β
  • TNF-α
  • VEGF

On-Demand Assay Design and Development

Our scientists will help to design and qualify study-specific biomarker assays and readouts for small and large research animal models. We can transfer and qualify assays, or develop them for you. Fast and accurate testing services are available once the assay is developed.

  • Therapeutic area-specific bioassays
  • Bioanalytical immunoassays
  • Infectious disease
  • Genetic biomarkers
  • Gene expression testing
  • Protein/phosphoprotein analysis
  • Plate-based apoptosis assays
  • Tumor profiling for target expression and modulation
  • Tumor sampling for in vivo preclinical study to monitor for target modulation
  • Cytokine analysis
  • Clinical biochemistry testing
  • Immunohistochemistry capabilities
  • Mouse and rat gene expression testing
  • Biobank resource of flash frozen samples of our in vivo portfolio available

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