Ion Channel Trafficking Assays

Functional ion channel activity can be hindered by prolonged exposure to drugs that inhibit trafficking of the channel protein from cytoplasmic sites to the surface membrane. HERG-Lite® and CHAN-Lite® are chemiluminescent assays that identify trafficking inhibition in cardiac cell lines following overnight drug exposure.


  • Determine specificity of drug-induced trafficking inhibition
  • Identify compounds that enhance cell-surface expression
  • Rapid results

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Conventional Patch Clamp

Serum Shift Assays

Manual patch clamp hERG inhibition assay performed in 100% fetal bovine serum (FBS, dialyzed) detects potency shifts due to protein binding.