At Charles River, we understand the challenges and complexities in the search of potential therapies for neurological disorders. Discovery from Charles River applies our multi-disciplinary skillset that spans biology, chemistry and pharmacology. Our portfolio of unique capabilities and state-of-the-art instrumentation can support and advance your central nervous system (CNS) research.

CNS Drug Discovery Video Highlights

View our CNS drug discovery videos to learn more about some of our capabilities.

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Our scientists have the depth and specialty expertise to deliver insight and data to progress your discovery program in all major neurodegenerative diseases and neurological indications, including depression, schizophrenia, Alzheimer’s disease, Parkinson’s disease, chronic pain, epilepsy, multiple sclerosis, stroke and ischemia. To improve the lives of patients impacted by deadly or debilitating rare or orphan diseases, such as ataxia, Rett syndrome and Batten disease, our scientists continuously develop innovative new models and assays to advance research in these neglected disease areas.

Our scientific team can guide you in selecting the appropriate disease model or assay, validating targets, identifying hits and optimizing leads. With our extensive portfolio, we can collaborate with you to develop novel study designs to meet your specific research needs. To further efficacy, metabolic, toxicokinetic and bioanalytical investigations, we offer fully validated in vitro services and capabilities. Our various new and cutting edge imaging modalities, comprehensive behavioral and biomarker endpoints, and translational tools enable more effective decision-making in development and help move your research forward.

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Key Ligand-Gated Ion Channels

This webinar focuses on studies of neurotransmitter-activated ion channels as well as GABAA, NMDA, and nicotinic acetylcholine receptors, in that they are validated therapeutic targets in several neurological disorders.

Posters at Neuroscience 2016

Charles River presented a number of scientific posters focusing on Alzheimer’s disease, Parkinson’s disease, Huntington’s disease and neurodegeneration.