Neuromuscular Deficiency Testing

Muscular deficiencies are often associated with central and peripheral neuronal diseases. Charles River offers multiple neuromuscular models, including X-linked muscular dystrophy (MDX) mice for Duchenne muscular dystrophy and experimental allergic encephalomyelitis (EAE) rats and mice for multiple sclerosis. The end-point measurements include basic monitoring and behavioral testing, as well as imaging to assess neuromuscular degeneration and metabolic changes.

The neuromuscular disease service offers phenotyping and efficacy testing of novel therapies. An efficient platform that supports lead selection combines the most relevant imaging modalities, robust sensory-motor behavior testing and biochemical assays—review the supporting data below. You can also read the full story or view a webinar replay.

Fine Motor Skill Impairment in MDX Mice

Trajectory maps from mice within the study. Clear changes in various parameters associated with gait occur with response to training—although changes in gait associated with age are also evident in the untrained groups. It is notable that changes in gait associated with training are greater in the MDX trained group than the MDX untrained group.

Kinematic Analysis of MDX Mice

Kinematic Analysis

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Home Cage Monitoring

We are now able to monitor and track the behavior of up to 5 animals in the same cage for periods of up to 9 months.

Imaging Services

Our imaging modalities can both increase the efficiency and enhance the value of your in vivo study.