Spinal Nerve Ligation Model

Considered one of the most suitable models for analgesic screening against neuropathic pain, the spinal nerve ligation (SNL) model is induced by unilateral ligation of the L5 and L6 branches of the spinal nerves. Stable mechanical tactile allodynia, as assessed by manual von Frey filaments, is observed from week 1 up to week 7 post-surgery. In addition to tactile allodynia, the model can be optimized for other endpoints, such as heat hyperalgesia and weight bearing, based on client’s request.

Baseline von Frey Thresholds in SNL Rats

Stable mechanical tactile allodynia, as assessed by manual von Frey filaments, observed from week 1 to 7 post-surgery.

Effects of Pregabalin on Tactile Allodynia in SNL Rats

In addition to our established spinal nerve ligation (SNL) model in rats, we offer a partial sciatic nerve ligation (PSNL) model, which recapitulates the neural pain associated with chronic constriction injury, as well as a model of chemotherapy-induced pain.

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