Oxaliplatin-Induced Neuropathic Pain Model

Neuropathic pain and nerve damage induced by chemotherapy agents such as oxaliplatin and cisplatin are dose-limiting side effects of cancer treatment. In order to develop next-generation chemotherapeutic agents with improved side effect profiles, better characterized animal models are required to test the novel agents.

Charles River scientists recently characterized the previously described the oxaliplatin mouse model’s response to cool allodynia, or pain in response to cooling, using two behavioral tests—the tail immersion/flick test and the acetone cooling test. Cool allodynia occurred during and after oxaliplatin infusion, and is thought to arise from a direct effect of oxaliplatin on peripheral sensory neurons. Review the key findings and select data below, or click here to download the full poster.

  • Exposure to oxaliplatin led to persistent cool allodynia in the acetone test, which is a reliable method to test oxaliplatin-induced peripheral neuropathy.
  • Treatment with nerve pain medications, pregabalin and duloxetine, alleviated the allodynia response.
  • There was significant variation within each group (control and treated) in the tail immersion/flick test, suggesting that the tail immersion/flick test is not a reliable method to measure cool allodynia.

The acetone cooling test is a reliable method to measure cool allodynia in control mice and oxaliplatin-induced pain mouse models.

Oxaliplatin model cool allodynia response

Tail immersion test over time. Significant difference in latency to tail flick response was seen in multiple, but not all, time-points.

Nerve pain medications helped alleviate cool allodynia in oxaliplatin-treated mice.

Oxaliplatin model cool allodynia reversal

You may also be interested in...

black mouse

Home Cage Monitoring

We are now able to monitor and track the behavior of up to 5 animals in the same cage for periods of up to 9 months.

Imaging Services

Our imaging modalities can both increase the efficiency and enhance the value of your in vivo study.