The brain's cholinergic system is implicated in cognitive processes. Scopolamine, a muscarinic cholinergic receptor antagonist, impairs learning and memory in both rodents and humans. Charles River conducts contract studies in established scopolamine-induced amnesia models in rodents to facilitate research and the development of compounds for Alzheimer's and other diseases with negative impact on memory and cognitive functions.
In mice, the cognitive tests used are contextual fear conditioning (CFC) and social transmission of food preference (STFP), both acknowledged as memory tests requiring hippocampal functions. In rats, we use the passive avoidance test and T-maze alternation learning.