CVN Mouse

The CVN mouse (APPSDI/NOS2 KO) provides a new tool for Alzheimer’s disease (AD) studies.

The mouse exhibits behavioral deficits as well as biochemical hallmarks of AD during aging. There is a marked inflammatory component in this mouse compared to the Tg2576 line, and amyloid plaques and insoluble amyloid beta are detectable in mice at 9 months of age.

Testing/Validation Data

Click below to see a sample data set.

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Webinar Replay

Learn how CVN mice better reflect the cascade of Alzheimer’s disease in humans because they address early amyloid deposition and inflammation through to later-stage hyperphosphorylated and aggregated native tau pathology.

Imaging Services

Our range of imaging modalities can dramatically increase the efficiency and significantly enhance the value of your study.