Impairment of fine motor skills is used as an early diagnosis marker in muscular degenerative and neurodegenerative diseases. In order to effectively test therapeutic compounds in animal models, it is imperative to characterize the relevant neurodegenerative and muscular degenerative mouse models for fine motor impairment. However, there are limited instruments and assays available to test animal models for fine motor impairment.
Scientists at Discovery by Charles River recently used a novel automated and high-precision system, the MotoRater, to successfully analyze fine motor skills in mouse models of Huntington’s disease, Duchenne muscular dystrophy and other neurological diseases. The MotoRater fine motor kinematic analysis reveals early changes in muscular or neuronal function in disease models to support the development of therapeutics that reverse or slow progressive degeneration and to test compounds that can cause fine motor impairment as a side effect.
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You can review the kinematic data analysis below.