Atherosclerosis Models

Atherosclerosis is a disease state where artery walls thicken as a result of a buildup of fatty materials. At Charles River, plaque formation in ApoE-/- and LDLR-/- mice is used to assess anti-atherosclerotic agents in vivo. We have vast experience with these models, removing the aorta or brachiocephalic sinus and performing either cross-section or en face staining to augment the lumen, plaque formation and macrophage infiltration. Differences between control and treatment groups are compared to assess efficacy.

Assessing Cholesterol Metabolism in Animal Models for Drug Discovery

This webinar discusses rodent models that are commonly used to assess cholesterol absorption and metabolism. View now »

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Biomarker Services

We can support your drug discovery pipeline by providing biomarker analysis in a non-GxP environment.