Process & Scale-up Chemistry

Our integrated project teams are supported by a highly experienced and dedicated group of scale-up chemists (ex-Merck, Aventis, Roche, GSK and Ultrafine). Working with purpose-built reactor rigs (reaction temperature range <-70 ˚C up to 180 ˚C), large-scale synthesis and purification equipment, added value is delivered to customers by efficient in-house synthesis of key project intermediates (up to kilogram quantities) and active pharmaceutical ingredients (up to ~500 g quantities) for preclinical toxicological studies.

As integrated drug discovery projects progress towards late-stage lead optimization, members of the scale-up team are deployed within the project teams to engage in early process chemistry research and development support. This enables seamless process transfer to our client's pilot plant, or to a CRO of their choice, thus avoiding delays that are often experienced post candidate nomination.

  • Redesign and optimization of synthetic routes
  • Compound purification and isolation improvements
  • Isolation and characterization of side products
  • Physical form monitoring
  • Generation of early calorimetric data
  • Management of other specialist CROs
  • Provision of full technical transfer documentation
  • Interchangeable thermal jacketed reactors (2, 5, 10 and 20L)
  • 5-20L flange-flask reaction glassware
  • High-capacity Interchim Puriflash® 4100
  • 20L Buchi evaporator

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Pharmaceutical Sciences

Pharmaceutical Sciences

Our pharmaceutics experts provide essential information to help direct medicinal chemistry and de-risk potential drug candidates.

Scientific Resources

Our innovation is reflected in patent applications (where our scientists appear as joint inventors on client projects) and in our posters and publications.