LPS-Induced Cytokine Release Model

Charles River conducts contract studies in a validated animal model of cytokine release to test the efficacy of novel therapeutics. This model is easily modified to address client-specified study needs.

For our initial validation study, each mouse receives a lipopolysaccharide (LPS) injection. At specified time points post-LPS challenge, blood is collected for cytokine analysis (e.g., TNF, G-CSF, IL-6, IL-1B). Client studies would compare treated groups against control animals.

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