DSS Model | TNBS Model | Poly I:C Model
Dextran sulfate sodium (DSS) is a sulfated polysaccharide with variable molecular weights. Administration of DSS causes human ulcerative colitis-like pathologies due to its toxicity to colonic epithelial cells, which results in compromised mucosal barrier function. Clinical observations similar to human pathologies, such as weight loss, diarrhea and occult blood in stool, are commonly observed and measured in the DSS model. Importantly, studies suggest that acute DSS colitis mostly involves activation of neutrophils and macrophages, while lymphocytes are also activated in chronic DSS colitis.
At Charles River, we offer both the acute and chronic DSS-induced colitis model in mice, which includes in-life clinical evaluation, histopathological evaluation of colon sections and optional cytokine and myeloperoxidase (MPO) activity analysis.
Dextran Sodium Sulfate Colitis Mouse Model: Traps and Tricks J Biomed Biotechnol, 2012. 718617.
Chemically Induced Mouse Models of Intestinal Inflammation. Nat Protoc, 2007. 2(3):541-6.