Solubility, Dissolution & Stability

Charles River can measure the solubility, dissolution and stability of compounds under a variety of conditions. These data, together with Caco-2 permeability measurements produced by in vitro ADME screening, can be used to provide an early Biopharmaceutics Classification System (BCS) class for a compound.

Services

  • Kinetic solubility measurement
  • Thermodynamic solubility measurement
  • pH solubility measurement
  • Solubility/Stability measurements in lung, gastric and intestinal fluid mimetics
  • Dissolution of API and early IMP formulations (paddle and flow-through)

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In Vitro ADME Screening

Essential information on potential vulnerabilities of compounds to help direct medicinal chemistry activities.

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Integrated Drug Discovery

Advance your project from target identification to the clinic with Charles River’s integrated capabilities.