Assessment of the irritation potential of chemicals is a key element in their safety evaluation. Traditionally, these tests have been conducted in rodents and rabbits. Charles River offers a number of ocular irritation and serious eye damage models that may be used in replacement of acute ocular testing. The models may be used early in the development of the test article as a screen or during GLP toxicology testing. Screening and GLP versions of the BCOP, EpiOcular and HCE Eye assays are available.