Angiogenesis Model

The study and development of anti-angiogenic therapies depends on reliable and reproducible stimulation models of neovascular response. Charles River has several experimental techniques that allow an effective examination of short-term neovascularization and angiogenic response to bFGF, VEGF or other angiogenic stimuli:

Corneal Micropocket Assay

  • Hydron pellet prepared with growth factors chosen for specific study requirements
  • Surgical implantation of pellet into a corneal micropocket
  • Corneal neovascularization measured using slit-lamp microscope
  • Short-term study with rapid turnaround times

In Vivo Screens Using Angiogenic-Dependent
Tumor Growth

  • Bevacizumab can be used as a positive control.

Metronomic Dosing1

  • Long-term, low-level dosing of cytotoxics or other agents of interest to inhibit growth and development of vascular endothelium while avoiding whole-animal toxicity
  • Metronomic dose determination for use in efficacy study
  • Studies can last up to 90 days

1. Browder, 2000; Cancer Research 60:1878

Testing / Validation Data

Click below to see a sample data set.

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