The study and development of anti-angiogenic therapies depends on reliable and reproducible stimulation models of neovascular response. Charles River has several experimental techniques that allow an effective examination of short-term neovascularization and angiogenic response to bFGF, VEGF or other angiogenic stimuli:
Corneal Micropocket Assay
Hydron pellet prepared with growth factors chosen for specific study requirements
Surgical implantation of pellet into a corneal micropocket
Corneal neovascularization measured using slit-lamp microscope
Short-term study with rapid turnaround times
In Vivo Screens Using Angiogenic-Dependent
Bevacizumab can be used as a positive control.
Long-term, low-level dosing of cytotoxics or other agents of interest to inhibit growth and development of vascular endothelium while avoiding whole-animal toxicity
Metronomic dose determination for use in efficacy study
Studies can last up to 90 days
1. Browder, 2000; Cancer Research 60:1878
Testing / Validation Data
Click below to see a sample data set.