Cachexia Model

The Yoshida ascites hepatoma model induces cachexia and produces tissue wasting, particularly in skeletal muscle. This very aggressive, short-term model is used to evaluate the anticachectic effects of a therapy. With therapies typically beginning on the first day and continuing to the end of the study, the heart, gastrocnemius muscle and ascites are measured at sacrifice and used to evaluate efficacy of the therapy.

Charles River at AACR Annual Meeting 2017

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