Ovalbumin (OVA)-induced Allergic Asthma Model

The ovalbumin (OVA)-induced asthma model in the Brown Norway rat and mouse is used to assess the in vivo efficacy of anti-asthma drugs. This animal model features many similarities to human allergic asthma, including the presence of eosinophilic lung inflammation, the release of inflammatory mediators and cytokines, and the presence of airway hyperresponsiveness after the antigen-challenge. Total and differential cell counts of inflammatory cells in the lung are performed on the bronchoalveolar lavage (BAL) fluid at various time points to observe the time course of inflammation and evaluate the effects of compounds. Additional services that can be combined with this asthma model include assessment of inflammatory mediators and histopathological evaluation.

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