Mucociliary Clearance Model

(Under Development)

Mucociliary clearance is an important defense mechanism for clearing the lungs of bacteria and particulate matter. In a variety of airway diseases (e.g., COPD, asthma and cystic fibrosis), this becomes dysfunctional, leading to airway inflammation, obstruction and epithelial damage. Smoking has also been shown to cause a reduction in mucociliary clearance rate in humans.

Charles River is establishing models of mucociliary clearance (MCC) utilizing fluorescent beads administered to the trachea of guinea pigs to determine clearance rate.

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