House Dust Mite (HDM)-induced Allergic Asthma Model

The House Dust Mite (HDM)-induced asthma model in the mouse is used to assess the in vivo efficacy of anti-asthma drugs. This model features many similarities to human allergic asthma, including the presence of eosinophilic lung inflammation and the release of inflammatory mediators and cytokines primarily associated with Th2-type inflammation. Total and differential cell counts of inflammatory cells in the lung are performed on the bronchoalveolar lavage (BAL) fluid at various time points to observe the time course of inflammation and evaluate the effects of compounds. Additional services that can be combined with this asthma model include inflammatory mediators, histopathologic evaluations and assessments of airway hyperresponsiveness. The model is robust and reproducible and sensitive to steroids (both oral and inhaled). 

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