Bleomycin-induced pulmonary fibrosis is the most common experimental study model of human lung fibrosis. Charles River has developed mouse and rat models of bleomycin-induced lung fibrosis and has established time courses of effect over a 28-day period post-bleomycin administration.
We have the capability to deliver test items by multiple routes (e.g., oral, inhalation, intravenous, subcutaneous). Test item efficacy is then monitored by a number of methods:
Histopathology and qualification via a modified Ashcroft score
Collagen quantification (directly or via image analysis of lung sections)
Bronchoalveolar fluid (BALF) analysis
Respiratory measurements (conscious, in-life assessments)