Pulmonary Fibrosis Model

Bleomycin-induced pulmonary fibrosis is the most common experimental study model of human lung fibrosis. Charles River has developed mouse and rat models of bleomycin-induced lung fibrosis and has established time courses of effect over a 28-day period post-bleomycin administration.

We have the capability to deliver test items by multiple routes (e.g., oral, inhalation, intravenous, subcutaneous). Test item efficacy is then monitored by a number of methods:

  • Histopathology and qualification via a modified Ashcroft score
  • Collagen quantification (directly or via image analysis of lung sections)
  • Bronchoalveolar fluid (BALF) analysis
  • Respiratory measurements (conscious, in-life assessments)

Webinar Replay

Disease Relevant In Vitro and In Vivo Models for Lung Fibrosis

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Poster Download

Log in to the Source℠ to view this poster, which aims to develop and validate a bleomycin-induced ex vivo and an in vivo pulmonary fibrosis model.

Poster Download

Log in to the Source℠ to view this poster, which examines a precision-cut lung slice model to develop and validate an ex vivo pulmonary fibrosis model.