The Complete Freund's Adjuvant/House Dust Mite (HDM)-induced severe asthma model in the mouse is used to assess the in vivo efficacy of anti-asthma drugs with the potential to treat severe asthma. This model features many similarities to human severe asthma, including the presence of both neutrophilic and eosinophilic lung inflammation, the release of inflammatory mediators and cytokines primarily associated with both Th1- and Th2-type inflammation and a relative steroid insensitivity. Total and differential cell counts of inflammatory cells in the lung are performed on the bronchoalveolar lavage (BAL) fluid at various time points to observe the time course of inflammation and evaluate the effects of compounds. Additional services that can be combined with this asthma model include profiling of inflammatory mediators, histopathologic evaluations and assessments of airway hyperresponsiveness. The model is robust, reproducible and insensitive to steroids (both oral and inhaled).