Charles River can develop, validate and apply quantitative bioanalytical methods for the determination of pharmaceutical compounds ranging from small molecules to larger proteins. Our laboratories have the latest instrumentation to measure drug and metabolite concentrations in biological matrices using a wide range of techniques and technology platforms. This variety of advanced equipment ensures that we have the capacity to support you with rapid lead-in times in order to meet critical deadlines. Full support for capillary microsampling and dried blood spot (DBS) analysis is also offered.

All studies are supported by a validated Watson™ Laboratory Information Management System (LIMS) for efficient collation and reporting of data.

  • 96-well plate automated sample extraction
  • High-throughput microcolumn analysis
  • Liquid chromatography/tandem mass spectrometry (LC-MS/MS)
  • Liquid chromatography/mass spectrometry (LC-MS)
  • Gas chromatography mass spectrometry (GC-MS)
  • High performance liquid chromatography (HPLC)
  • Gas chromatography (GC)
  • Capillary electrophoresis (CE)
  • Hybridization assays for oligonucleotides
  • Immunoassays

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Safety Assessment

Full range of toxicology and safety testing that meets the appropriate regulatory requirements.

Drug Metabolism and Pharmacokinetics

Metabolism and clinical pharmacokinetic laboratories offer fully validated, networked data management systems for radioisotopic, chromatographic and pharmacokinetic evaluations.