Formulation development services range from preformulation investigations to analytical method development and validation. Charles River prepares formulations based on our extensive knowledge of vehicle suitability in animal models. Formulation types include oral, parenteral, inhalation and radiolabeled. Bulk test articles are analyzed for determination of identity, purity and stability to support GLP preclinical studies.

Adhering to strict regulatory guidelines, test article receipt, storage, distribution, use and disposition are controlled by dedicated staff with several facilities operating a barcode system for identifying and monitoring materials.

  • pH solubility profiling assessments
  • Dose suitability
  • Compatibility
  • Bioavailability enhancement
  • High performance liquid chromatography (HPLC)
  • Ultra-high performance liquid chromatography (UPLC)
  • Gas chromatography (GC)
  • Liquid chromatography/mass spectrometry
    (LC-MS and LC-MS/MS)
  • Atomic absorption spectroscopy (AAS)
  • Capillary electrophoresis (CE)
  • UV/Vis spectroscopy
  • Fourier transform infrared (FTIR) spectroscopy
  • Karl Fischer

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Leading the industry in the fields of reproductive toxicology, inhalation, infusion, bone research and other specialty toxicological assessments.