Endosafe® Endotoxin Testing

The bacterial endotoxin test has evolved into a highly sensitive and exquisitely specific in vitro assay that is used to protect humans from contaminated medical devices, cellular therapies, and parenteral products. As the most sensitive and robust assay available, limulus amebocyte lysate (LAL) has transformed from a qualitative gel-clot assay to a 15-minute quantitative assay available right on the production floor. Charles River has been at the forefront in the evolution of endotoxin testing, investing in the development of new technologies and innovative products to improve the quality of testing and accelerate the development process. We’ve purposely built our portfolio of FDA-licensed products for rapid and traditional bacterial endotoxin testing to reduce retest rates and improve turnaround times so you can make prompt, confident decisions about the safety of your products.

lab technician using Endosafe Nexus

Endotoxin Testing Systems

Rapid testing systems for quantitative endotoxin analysis, glucan contamination and gram identification.

horseshoe crabs in sand

Atlantic Horseshoe Crab Conservation

Our conservation efforts and animal welfare practices have helped preserve the horseshoe crab population.

nexgen-PTS cartridges

Endosafe® Cartridge Technology

Our LAL cartridge technology is our innovative response to our customers’ need for higher sensitivity and faster quantitative results.

vial of endotoxin-specific buffer sitting on rack of test tubes

Limulus Amebocyte Lysate (LAL)

Our team has developed and optimized a range of formulations that provide increased sensitivity and greater linearity.