Endosafe®-MCS™

Charles River is committed to producing environmentally friendly products as part of the EU Directive on Restriction of the use of certain Hazardous Substances (RoHS). With the launch of the Endosafe® nexgen-MCS™ and as part of our End-of-Life policy, the original Endosafe®-MCS™ (MCS100K and MCS550K) will be discontinued on June 30, 2017. We will be releasing the Endosafe® nexgen-MCS™ on July 1, 2017 which will consist of upgraded components in an effort to ensure compliance with the RoHS directive. Support for first generation systems (including parts, maintenance and calibration) will continue through December 31, 2022. Beginning in 2023, support for first generation MCS™ systems will be limited. For further information regarding our end-of-life policy, reference our frequently asked questions document.

The Endosafe®-MCS™ is a multi-cartridge system that utilizes FDA-licensed disposable cartridges for accurate, convenient endotoxin testing. This bench-top test system is comprised of five individual spectrophotometers built into a unit that runs with your PC and EndoScan-V™, our endotoxin-measuring software.

Disposable cartridges used to run an assay contain precise amounts of LAL reagent, chromogenic substrate and control standard endotoxin (CSE). Since each cartridge runs independently, you can run your samples as needed and not wait for a full batch of samples for testing.

  • Test multiple samples simultaneously
  • Samples run independently, allowing for random access
  • High throughput for real-time results
  • Single-step, semi-quantitative LAL test
  • Uses FDA-licensed LAL cartridges
  • LAL test components all included in cartridges
  • Results can be analyzed via EndoScan-V™ endotoxin measuring software.
  • Sophisticated data management and reporting capabilities
  • Samples can be traced to the individual spectrophotometer used to perform the assay.
  • Four levels of sensitivity are available as testing options: 0.005, 0.01, 0.05 and 0.10 EU/ml.
  • No microbiology training is required; anyone can run this simple assay.
  • System qualification and validation support is provided if needed.

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Endosafe®-MCS™ User Information

Access the Endosafe® Customer Web Portal for instant access to package inserts, registration documents, warranty forms and user guides.

Product Validation Using the MCS™

Product Validation Using the MCS™

The Endosafe®-MCS™ and FDA-licensed LAL cartridges are validated for BET and can be used for product validation for both previously validated samples and new products.

Endosafe® Cartridge Compliance

Understand how our FDA-licensed LAL cartridge technology is compliant with existing global harmonized regulatory guidelines.