Biotransformation describes the conversion of a compound to a metabolite through the action of enzymes. Charles River offers a comprehensive service for the isolation, analysis and identification of metabolites in biological matrices in support of drug safety studies. This service can be provided as part of a full ADME package or as a stand-alone study.
Additionally, a synthetic chemistry service is available to undertake synthesis of metabolites, reference standards and internal standards to assist with method development and metabolite identification.
Technical Capabilities
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Radiometric profiling
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HPLC/UPLC
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LC-MS and LC-MS/MS
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GC-MS and ion trap MS
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CE for oligonucleotides
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TOF, MALDI-TOF and ion mobility
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Organic chemistry metabolite synthesis