In vitro ADMET parameters are a set of factors that describe how a drug behaves in the human body and can be a major cause of drug failure. By focusing on in vitro ADMET data you can predict at an early stage which compounds not only possess good binding affinity for a specific target, but also pass the test for good bioavailability and safety. Our wide range of automated in vitro assays yields information in the areas of metabolism, toxicity and physicochemical characteristics.
Assays
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Aqueous solubility
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Cytochrome P450 enzyme inhibition
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Cytochrome P450 induction
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Cytochrome P450 reaction phenotyping
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Cell permeability and efflux assays (CaCo-2)
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Cell proliferation and cytotoxicity
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Drug-drug interaction
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Enzyme assays
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hERG inhibition
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Metabolic plasma and buffer stability
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Metabolite profiling
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Metabolite assessment and identification
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Plasma protein binding