Pharmacokinetics

The Pharmacokinetics group at Charles River works closely with other operational departments to provide pharmacokinetic data for animal and human radiolabelled studies, human clinical trials as well as veterinary clinical studies in a timely fashion utilizing industry-standard WinNonlin® software.

Our pharmacokinetic consultancy service provides advice and support for all aspects of clinical pharmacokinetics and is offered as part of a complete development program, as a full-service single-study package, or as a stand-alone service. Upon request, pharmacokinetic parameter estimation output and reports may include a comprehensive text interpretation of the data.

  • Input into study design, including preclinical-to-clinical considerations (e.g., allometric scaling) utilizing information from preclinical toxicokinetic studies
  • Noncompartmental pharmacokinetics
  • Compartmental pharmacokinetics/simulations
  • Ascending dose (assessment of dose proportionality)
  • Repeat dose (assessment of multiple-dose linearity)
  • Bioavailability and bioequivalence
  • Drug interaction studies
  • Special populations
  • Pharmacodynamic and pharmacokinetic/pharmacodynamic modeling
  • Deconvolution
  • Maximum concentration (Cmax)
  • Time of maximum concentration (Tmax)
  • Area under concentration time curve (AUC0-∞ and AUClast)
  • Volume of distribution (Vz)
  • Clearance (CL)
  • Terminal elimination half-life (t1/2)
  • Bioavailability

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