Translational Biomarkers

From early discovery stages through clinical support, translational biomarkers are used to identify a compound’s impact on organs or tissues before a clinical effect is evident. Biomarkers are divided into three general classes: target biomarkers, mechanism biomarkers and disease biomarkers. Choosing the right translational biomarker is based on whether it is detectable, measurable and, in the end, able to be qualified or validated. Charles River advises on selecting the appropriate biomarker, analytical methodology and pull through from nonclinical to clinical use. Our biomarkers services include:

  • Fit for purpose to full compliance
  • Full method development, transfer or commercial kit optimization
  • Qualification or validation of target specific assays

The following are fluid biomarkers assay examples:

  • Lipids
  • Endocannabinoid-related compounds: AEA, OEA, PEA and LEA
  • Nucleosides and nucleotides
  • Small organic acids
  • Endocrines
  • Neurotransmitters

You may also be interested in...

Biomarker Services Overview

Our comprehensive global portfolio will support you every step of the way, from novel biomarker identification to animal models and testing, through safety assessment and clinical support

Immunology Services

We perform assessments for the global registration of pharmaceutical and biotechnology compounds.

scientist at a computer

Biomarker Webinar Series Replay

Our panel of biomarker experts presented a webinar series addressing the various classes of biomarkers, including clinical pathology, immunology and imaging markers, and their use for effective translation into clinical tools.