Metabolite Profiling & Identification

Charles River offers a comprehensive service for the isolation, analysis and identification of metabolites from biological matrices in support of compound safety and metabolism studies.

Our biotransformation chemists have many years of experience in the following areas:

  • Chromatography method development
  • Sample preparation method development
  • Extraction of bound residues
  • Radiochromatographic profiling
  • Isolation and purification of metabolites
  • Metabolite identification using LC-MS/MS, QToF
    and IT-ToF
  • Access to NMR
  • Expert report preparation
  • Radiosynthesis

Charles River can assist with the procurement of radiolabeled molecules on behalf of clients. This service is totally confidential, free of charge and does not commit the client to using either Charles River or any of the laboratories involved. Additionally, we have chemists on-site who are experienced in the handling and repurification of radiolabeled molecules, which allows us to preserve study timelines when radiolabeled molecules are unstable or impure.

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Physicochemical Characterization

We offer a full range of physicochemical testing to meet all regulatory requirements, either as full testing programs or stand-alone tests.

Field Trials

Field Trials

Charles River runs field trials from GLP- and GEP-accredited field bases located throughout northern and southern Europe.

Residue Analysis

Using samples from studies conducted at Charles River, or provided by you, we can develop assays or evaluate and modify a supplied method using a full suite of analytical techniques and instrumentation.

5-Batch Analysis

Charles River has been conducting these tests since 1990, carrying out many successful programs involving various pesticide classes, including insecticides, herbicides, fungicides and biocides.