Inhalation Toxicology

Inhalation is the primary method for delivering pharmaceuticals to patients with lung or airway diseases and is also a leading route of unintended exposure during manufacturing or use of (agro)chemicals. With a team of dedicated inhalation toxicologists, technologists and specially equipped laboratories, Charles River offers a full range of inhalation toxicology services to support the worldwide registration of pharmaceuticals, agrochemicals and chemicals.

Our vast experience includes specialized efficacy and toxicology studies, selection of inhaled drug formulations and inhalation delivery systems, design of appropriate analytical methodologies and dosage estimation in animal models.

Need Guidance Designing an Inhalation Tox Study »

Study Types

  • Neonatal and reproductive inhalation
  • Neurotoxicologic
  • Immunologic sensitization via inhalation
  • Intranasal
  • Intratracheal
  • Anti-asthmatic efficacy
  • Acute to sub-chronic and chronic through to carcinogenicity
  • Whole body, nose-only, oronasal, and head-only
  • Radiolabeled aerosol studies

To support toxicology studies, we provide services such as micronisation/jet milling (including PSD analysis) and media milling. For respiratory measurements, we provide the following:

  • Fleisch Pneumotach (nonrodents)
  • Respiratory Inductive Plethysmography (available Q4 2017 – nonrodent species)
  • Head Out Plethysmography (rodents)
    • Nose-cone adaptation for during dosing respiratory assessment
  • Pressureized metered dose inhalers (MDIs)
  • Dry powder generators
  • Nebulizers
  • Atomizers
  • Emulsion sprays
  • Vapors and gases
  • Nano and colloidal
  • Compound-specific methodologies can be developed and validated
  • Filters or impingers are used to sample exposure atmospheres
  • Chemical or gravimetric assessment of test atmospheres
  • Online infrared or gas chromatography analysis for gas and vapor atmospheres
  • Real-time aerosol monitors for qualitative assessment of aerosol atmosphere
  • Aerosol particle size distribution monitored using cascade impactors or laser optical systems

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Miss Us at SOT 2017?

Access the recordings of our four exhibitor sessions and downloadable versions of our poster presentations from SOT 2017.

Scientific Poster

Selecting a suitable aerosol generation set up must be considered as part of the nonclinical testing program. This poster compares two aerosol generation devices and the ability to achieve target aersol.