Genetic Toxicology

Genetic toxicology helps discern the possibility of heritable mutations, developmental defects, cancer initiation, aging and other long-term adverse genetic effects.

Charles River performs genetic toxicology testing as part of a comprehensive safety assessment program or as a stand-alone service. We offer a standard battery of in vitro assays and associated versions, as well as in vivo testing using all routes of administration.

Genetic toxicology datasheetGenetic Toxicology Facilities and Services

This datasheet provides a comprehensive list of in vitro and in vivo assay to support screening, regulatory and mechanistic assays.

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  • Ames test (bacterial reverse mutation)
  • Screening assay: Ames MPF, Ames II, mini Ames
  • Mouse lymphoma assay using L5178Y cells
  • Chromosome aberration test using human lymphocytes
  • Micronucleus test using human lymphocytes
  • Comet assay (CHO-K1, human blood lymphocytes)
  • Micronucleus (mouse, rat)
  • Bone marrow chromosome aberration (mouse, rat)
  • Unscheduled DNA synthesis test (rat)
  • Comet assay (rat)
  • Combined comet/micronucleus assay (rat)

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In Vitro Services

These services support metabolic, toxicokinetic and bioanalytical investigations with both qualitative and quantitative data.