Tolerance, Safety & Metabolism Studies

Charles River performs ADME, pharmacokinetic, bioequivalence, residue depletion and target animal safety studies in compliance with EU, VICH, US and Japanese regulations. We have experience in formulating doses ranging from aquatic-based solutions to oil-based suspensions. Our modern facilities offers enough housing capacity for over 200 lactating cattle.

We offer an integrated analytical service for clinical pathology, residue analysis, and metabolite profiling and identification. 

Tolerance Testing in Target Animals

Our experts can design tolerance studies in target animals to meet specific requirements for regulatory submissions. Flexibility in protocols allows us to pay special attention to the in-life use of the product with careful selection of dose levels and animal group sizes.

  • Cattle
  • Sheep
  • Goat
  • Pig (including neonatal)
  • Poultry
  • Marine and freshwater fish
  • Topical and dermal
  • Oral (dietary, capsule or gavage)
  • Intravenous
  • Intraperitoneal
  • Intramuscular
  • Subcutaneous

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Analytical Support

We offer full analytical support for quantifying residues and identifying metabolites.

Veterinary Field Studies

As well as efficacy and safety, we can conduct certain dose confirmation and post-marketing studies in the field. Treatment routes have included injectables, intramammaries, water medications, oral dosing and in-feed medications.