Inhalation Toxicology

With decades of experience, Charles River offers a full range of inhalation toxicology study designs to support the worldwide registration of pharmaceuticals, agrochemicals and chemicals. Our expert toxicologists work within our modern inhalation laboratory facilities, which are equipped with custom-designed apparatus for a variety of inhalation toxicology studies in multiple species.

Our experience includes specialized studies to demonstrate efficacy or pharmacotoxicity, the selection of inhaled drug formulations and inhalation delivery systems, design of appropriate analytical methodologies and the estimation of dosage in animal models.

For additional information on our inhalation toxicology capabilities, visit the Source℠.

Study Types

  • Reproductive inhalation
  • Immunologic sensitization via inhalation
  • Intranasal
  • Intratracheal
  • Anti-asthmatic efficacy
  • Neonatal inhalation
  • Acute to chronic toxicity, plus carcinogenicity
  • Nose-only, oronasal and head-only
  • Radiolabeled aerosol studies
  • Metered dose inhalers (MDIs)
  • Dry powder inhalers (DPIs)
  • Nebulizers
  • Atomizers
  • Emulsion sprays
  • Vapors and gases
  • Compound-specific methodologies can be developed and validated
  • Sorbent tubes or impingers are used to sample test atmospheres
  • Chemical or gravimetric assessment of test atmospheres
  • Online infrared or GC analysis for gases and vapors
  • Real-time aerosol monitors (RAM-S) for measuring particulates
  • Aerosol particle size distribution monitored using cascade impactors or laser optical systems

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