Histology & Histopathology

Histology

We offer full-service histology laboratories in both the US and Europe. Each of our laboratories is a high-production environment that emphasizes tissue accountability during every step of preparation and processing.

Laboratory managers, supervisors and section leaders monitor all aspects of histology, ensuring that SOPs are maintained and work is performed according to specific study protocols. All activities go through critical phase inspections by our Quality Assurance Unit, which operates independently of all project activities, assuring compliance with GLP requirements.

Histopathology

The full range of pathology services offered includes techniques from necropsy to sophisticated histological processing, as well as expert evaluation by our pathologists. For full tissue GLP projects, our pathologists evaluate tissue sections, compile observations utilizing our Provantis® data capture system and produce interpretative summaries of lesions.

Additionally, our pathologists can enter information directly into clients’ own data capture systems, either remotely or on-site. Representative digital images can also be included in the report as required. We have several Aperio and Hamamatsu whole slide scanner systems within our network, which facilitates greater scientific interaction between our pathologists and partners.

If needed, we can conduct peer review and independent tissue review, which are performed in accordance with internal or external standard operating procedures.

In addition to standard hematoxylin and eosin (H&E) histology, we perform a wide variety of special stains and techniques, including immunohistochemistry and in situ hybridization. Stains are available for localization of carbohydrates, nucleic acids, polysaccharides, proteins, lipids, enzymes, mRNA and cellular structures. Other capabilities include:

  • Specialized histochemical stains for specific cellular components
  • Plastic processing (GMA) for producing thin sections in support of reproductive pathology and neuropathology
  • Plastic embedding (MMA) for microtomy of hard tissues and devices and peripheral nerves (Spurr’s resin)
  • Frozen tissue processing and sectioning

Our specialty pathology services include:

  • Evaluation of acute, subchronic, chronic/oncogenicity, developmental and reproduction studies
  • Immunopathology
  • Renal pathology
  • Reproductive pathology
  • Respiratory pathology
  • Hepatobiliary pathology
  • Juvenile pathology
  • Carcinogenesis studies
  • Morphometric/Stereological analysis
  • Cell proliferation assays (BrdU Ki67 and PCNA)

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Toxicology Services

Our team of scientists regularly designs and performs safety programs ranging from acute through chronic toxicity to carcinogenicity studies. We also offer a broad range of animal models and numerous routes of administration.

Carcinogenicity Testing

View our poster on the comparison of historical control parameters from carcinogenicity studies in rodents presented in March at the SOT 2016 annual meeting.