Musculoskeletal Pathology

Our fully integrated approach to bone pathology assists clients with study design, development strategies, regulatory submissions and project execution for therapeutics designed for the treatment and prevention of osteoporosis, osteoarthritis and bone regeneration. Our experienced pathologists, together with a team of highly trained technicians, provide focused and broad-based services in bone pathology, including:

  • Histomorphometry
  • Histology
  • Molecular biology

Charles River also provides comprehensive pathology-based services in the fields of metabolic bone disease and orthopedics. Our staff has expertise in the preparation of thick and thin sections of plastic-embedded undecalcified tissue, cryotomy of undecalcified specimens and the application of computer-assisted image analysis for histomorphometric/histologic measurements. The image analysis can quantify structural findings in both hard and soft tissue, as well as fluorochrome label-derived dynamic changes in bones.

Precise measurements of bone densitometry and bone architecture are crucial to evaluating the effects of disease or drug modification. Our state-of-the-art preclinical imaging laboratory offers high-throughput scanning of excised bones and in vivo scanning at clinically relevant sites. Our laboratory is equipped with standard and high-resolution radiology, DXA, QCT and micro-CT scanners for diagnostic and quantitative imaging.

Biomechanical strength measurements are the most critical endpoint in evaluating the effects of drug treatment on the integrity of bone and provide an important index of bone quality. Coupled with our expertise in imaging, bone strength measurements are correlated with bone densitometry parameters to evaluate the important relationship between bone mass and strength.

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Molecular Imaging

Watch our upcoming webinar which addresses the increasingly integral role in vivo imaging techniques play in drug development.

Musculoskeletal Toxicology

Our team of pathologists, veterinarians and surgeons offer a fully integrated service in the field of bone research to assess the safety and efficacy of musculoskeletal drugs and devices.