Neuropathology

Charles River combines experienced pathologists with a highly trained technical staff and well-designed laboratories to offer pathology services in the specialized area of neuropathology. We provide assistance in study design, development strategies and regulatory submissions for a wide variety of compounds affecting the nervous system. Each year, our scientists conduct over 30 GLP-compliant neuropathology studies in support of FDA and EPA regulatory submissions.

Neuropathology Services

  • Whole-body perfusion
  • Specialized nerve tissue embedding
  • Specialized staining capabilities
  • Electron microscopy (transmission electron microscopy and scanning electron microscopy)
  • Morphometric analysis
  • Immunohistochemistry

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Neurotoxicology Studies

We perform neurotoxicity screening tests for possible on- or off-target effects, specialized target tissue delivery, expanded investigative studies and developmental neurotoxicity.

Therapeutic Area: CNS

From animal models of disease to preclinical testing, we have developed the tools to assist clients in shortening the development cycle of compounds with neurological implications.

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Neuropathology Datasheet

Unlock exclusive information on our neuropathology capabilities on the Source℠, our secure portal for scientific resources.