Tissue Cross-Reactivity

Tissue Cross-Reactivity
Charles River can support your monoclonal antibody research with our expertise in the initial stages of safety assessment for therapeutic antibodies targeted for use in humans. We hold a full range of tissues from various animal species, including human.

For immunohistochemistry-based tissue cross-reactivity studies, we provide efficiency of scale in full compliance with Good Laboratory Practice (GLP) regulations and interpretation of findings, and can represent you in presenting to the applicable regulatory agencies.

Tissue-Based Biomarkers
We provide correlative studies that are designed as an adjunct to clinical trials. These studies assist in determining whether a drug is reaching the intended target and whether the drug will work the same way in humans as it has in animals. Because each project has its own unique requirements, our pathologists and scientists will work closely with you to identify which tissue-based biomarkers to assess.

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Our Biomarker Database

Our biomarker database streamlines your search by characterizing your options in one centralized, quick-reference repository. Browse our biomarkers by therapeutic area, toxicological indication and species.

Toxicology Services

Our exceptional team of scientists regularly design and perform safety programs ranging from acute through chronic toxicity to carcinogenicity studies.

IHC Stains

We have developed IHC stains in a wide variety of species and can supply stock tissue for each of these species. Login to the Source to learn more.